The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Sep. 05, 2017

Filed:

May. 20, 2016
Applicant:

Vertex Pharmaceuticals Incorporated, Boston, MA (US);

Inventors:

John Demattei, Berthoud, CO (US);

Adam R. Looker, Winchester, MA (US);

Bobbianna Neubert-Langille, Sudbury, MA (US);

Martin Trudeau, Shannon, CA;

Stefanie Roeper, Medford, MA (US);

Michael P. Ryan, Roxbury, MA (US);

Dahrika Milfred Yap Guerette, Cambridge, MA (US);

Brian R. Krueger, Cambridge, MA (US);

Peter D. J. Grootenhuis, San Diego, CA (US);

Fredrick F. Van Goor, San Diego, CA (US);

Martyn C. Botfield, Concord, MA (US);

Gregor Zlokarnik, La Jolla, CA (US);

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 215/56 (2006.01); C07C 229/66 (2006.01); C07D 215/233 (2006.01); C07C 69/96 (2006.01); G01N 33/50 (2006.01); G01N 33/68 (2006.01); C07C 68/02 (2006.01); C07C 201/08 (2006.01); C07C 213/02 (2006.01);
U.S. Cl.
CPC ...
C07D 215/56 (2013.01); C07C 68/02 (2013.01); C07C 69/96 (2013.01); C07C 201/08 (2013.01); C07C 213/02 (2013.01); C07C 229/66 (2013.01); C07D 215/233 (2013.01); G01N 33/5041 (2013.01); G01N 33/6872 (2013.01); Y02P 20/55 (2015.11);
Abstract

The invention provides a process for the preparation of a compound of Formula 1, comprising coupling a carboxylic acid of Formula 2 with an aniline of Formula 3 in the presence of a coupling agent.


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