The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 29, 2017
Filed:
Sep. 09, 2014
Zhejiang Medicine Co., Ltd. Xinchang Pharmaceutical Factory, Xinchang County, CN;
Shanghai Institute of Pharmaceutical Industry, Shanghai, CN;
Kuaile Lin, Xinchang County, CN;
Zhengyan Cai, Xinchang County, CN;
Jing Pan, Xinchang County, CN;
Weicheng Zhou, Xinchang County, CN;
Guofeng Wu, Xinchang County, CN;
Lirong Yue, Xinchang County, CN;
Dadong Shen, Xinchang County, CN;
Abstract
The present invention provides a method for preparing an intermediate compound of sitagliptin represented by formula I. The preparation method comprises: dissolving a compound represented by formula II into an organic solvent; and under the catalysis of fatty acid and effect of chlorosilane, performing a reduction reaction of carbon-carbon double bonds, so as to obtain the intermediate compound of sitagliptin represented by formula I, R being methyl or formoxyl. The preparation method of the present invention avoids precious metal as a catalyst, and accordingly, the cost is low, the post-treatment is simple, the product has a high yield, chemical purity and optical purity, and de % is greater than 99.6%, and the preparation method can be used in synthesis of sitagliptin and is suitable for industrial production.