The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Aug. 29, 2017

Filed:

Mar. 20, 2015
Applicant:

Samumed, Llc, San Diego, CA (US);

Inventors:

John Hood, San Diego, CA (US);

Sunil Kumar KC, San Diego, CA (US);

David Mark Wallace, San Diego, CA (US);

Gopi Kumar Mittapalli, San Diego, CA (US);

Brian Joseph Hofilena, San Diego, CA (US);

Chi Ching Mak, San Diego, CA (US);

Venkataiah Bollu, San Diego, CA (US);

Brian Eastman, San Diego, CA (US);

Assignee:

Samumed, LLC, San Diego, CA (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07D 401/12 (2006.01); C07D 231/56 (2006.01); C07D 401/14 (2006.01); C07D 405/14 (2006.01); C07D 401/04 (2006.01); C07D 405/12 (2006.01); C07D 498/08 (2006.01); C07B 59/00 (2006.01); A61K 31/416 (2006.01);
U.S. Cl.
CPC ...
C07D 231/56 (2013.01); C07B 59/002 (2013.01); C07D 401/04 (2013.01); C07D 401/12 (2013.01); C07D 401/14 (2013.01); C07D 405/12 (2013.01); C07D 405/14 (2013.01); C07D 498/08 (2013.01);
Abstract

Indazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present disclosure concerns the use of an indazole compound or analogs thereof, in the treatment of disorders characterized by the activation of Wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis, Alzheimer's disease, lung disease, fibrotic disorders, cartilage (chondral) defects, and osteoarthritis), the modulation of cellular events mediated by Wnt pathway signaling, and neurological conditions/disorders/diseases linked to overexpression of DYRK1A.


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