The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 01, 2017
Filed:
Mar. 08, 2013
The United States of America, As Represented BY the Secretary, Department of Health and Human Services, Washington, DC (US);
Duke University, Durham, NC (US);
The University of North Carolina AT Chapel Hill, Chapel Hill, NC (US);
Stavros Garantziotis, Chapel Hill, NC (US);
John W. Hollingsworth, Durham, NC (US);
Bryan P. Toole, Mt. Pleasant, SC (US);
Jian Liu, Chapel Hill, NC (US);
The United States of America, as represented by the Secretary, Department of Health and Human Services, Washington, DC (US);
Duke University, Durham, NC (US);
The University of North Carolina at Chapel Hill, Chapel Hill, NC (US);
Abstract
Described herein is the finding that hyaluronan antagonists that inhibit hyaluronan signaling are capable of inhibiting airway inflammation and airway hyperresponsiveness (AHR). The present disclosure provides a method of preventing or reducing AHR in a subject suffering from or at risk for AHR by administering a hyaluronan antagonist. Also provided is a method of treating an airway disease or disorder in a subject by administering a hyaluronan antagonist. Hyaluronan antagonists include, for example, heparosan and hyaluronan oligosaccharides (oHAs). In some embodiments, the hyaluronan antagonist is administered locally to the airway, such as with an inhaler or nebulizer.