The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 25, 2017
Filed:
Apr. 13, 2012
Dhananjay T. Tambe, Brighton, MA (US);
Jeffrey J. Fredberg, Sharon, MA (US);
James Butler, Brookline, MA (US);
Xavier Trepat, Barbera del Valles, ES;
Dhananjay T. Tambe, Brighton, MA (US);
Jeffrey J. Fredberg, Sharon, MA (US);
James Butler, Brookline, MA (US);
Xavier Trepat, Barbera del Valles, ES;
President and Fellows of Harvard College, Cambridge, MA (US);
Abstract
Disclosed are systems, apparatus, devices and methods, including a method that includes determining traction forces exerted by a cellular monolayer on a substrate on which the monolayer is placed, and determining internal forces within and between cells of the monolayer based on the determined traction forces. In some embodiments, determining the internal forces of the cellular monolayer may include determining internal stresses within the cellular monolayer that act to balance the determined traction forces over at least part of the cellular monolayer. In some embodiments, determining of the internal stresses may also include setting boundary conditions at a boundary determined based on an optical field of view of an observed section of the monolayer.