The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 18, 2017
Filed:
Jul. 11, 2016
Zymogenetics, Inc., Princeton, NJ (US);
Pallavur V. Sivakumar, Copenhaven, DK;
Debra G. Gilbertson, Lake Forest Park, WA (US);
Marshall D. Snavely, Redmond, WA (US);
George R. Mabry, Seattle, WA (US);
Eugene C. Yi, Mill Creek, WA (US);
Yue Yao, Issaquah, WA (US);
Scott R. Presnell, Seattle, WA (US);
ZYMOGENETICS, INC., Princeton, NJ (US);
Abstract
Disclosed are antagonists of PDGF receptor β (PDGFRβ) and VEGF-A, including neutralizing anti-PDGFRβ and anti-VEGF-A antibodies, as well as related compositions and methods. Anti-PDGFRβ and anti-VEGF-A antibodies disclosed herein include bispecific antibodies capable of binding and neutralizing both PDGFRβ and VEGF-A. Also disclosed are methods of treating an neovascular disorder, such as cancer or an neovascular ocular disorder, using a PDGFRβ and/or VEGF-A antagonist.