The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 13, 2017

Filed:

Nov. 28, 2013
Applicant:

Showa Denko K.k., Tokyo, JP;

Inventors:

Hirobumi Aoki, Tokyo, JP;

Yuzuru Kokido, Tokyo, JP;

Yoko Hashimoto, Tokyo, JP;

Tadashi Yoneda, Tokyo, JP;

Assignee:

SHOWA DENKO K.K., Tokyo, JP;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12P 7/18 (2006.01); C12N 9/90 (2006.01); C12N 9/88 (2006.01); C12N 9/10 (2006.01); C12N 9/04 (2006.01); C12N 15/52 (2006.01);
U.S. Cl.
CPC ...
C12P 7/18 (2013.01); C12N 9/0006 (2013.01); C12N 9/1029 (2013.01); C12N 9/88 (2013.01); C12N 9/90 (2013.01); C12N 15/52 (2013.01); C12Y 101/01035 (2013.01); C12Y 101/01036 (2013.01); C12Y 101/01157 (2013.01); C12Y 203/01009 (2013.01); C12Y 402/0112 (2013.01); C12Y 402/01017 (2013.01); C12Y 402/01055 (2013.01); C12Y 402/01119 (2013.01); C12Y 503/03003 (2013.01);
Abstract

A method of manufacturing 1,4-butanediol through acetyl-CoA, acetoacetyl-CoA, 3-hydroxybutyryl-CoA, crotonyl-CoA, and 4-hydroxybutyryl-CoA by using a microbe and/or a culture thereof, wherein the microbe in the manufacturing method for 1,4-butanediol includes any one of genes among (a) a gene that has a base sequence of sequence number 1, (b) a gene that has a base sequence such that one or more bases are deleted, substituted, or added in a base sequence of sequence number 1, wherein the gene has a base sequence with an identity greater than or equal to 90% with respect to the base sequence of sequence number 1, and (c) a gene that hybridizes with a gene that has a base sequence complementary with a gene that has a base sequence described in sequence number 1 on a stringent condition, and includes any one or more genes among (d) genes that have base sequences of sequence numbers 2 to 9, (e) genes that have base sequences such that one or more bases are deleted, substituted, or added in base sequences of sequence numbers 2 to 9, wherein the genes have base sequences with an identity greater than or equal to 90% with respect to original base sequences thereof, and (f) genes that hybridize with genes that have base sequences complementary with genes that have base sequences of sequence numbers 2 to 9 on a stringent condition.


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