The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 13, 2017
Filed:
Nov. 03, 2011
Pavel Strop, San Mateo, CA (US);
Magdalena Grazyna Dorywalska, Redwood City, CA (US);
Arvind Rajpal, San Francisco, CA (US);
David Shelton, Oakland, CA (US);
Shu-hui Liu, Redwood City, CA (US);
Jaume Pons, San Bruno, CA (US);
Russell Dushin, Old Lyme, CT (US);
Pavel Strop, San Mateo, CA (US);
Magdalena Grazyna Dorywalska, Redwood City, CA (US);
Arvind Rajpal, San Francisco, CA (US);
David Shelton, Oakland, CA (US);
Shu-Hui Liu, Redwood City, CA (US);
Jaume Pons, San Bruno, CA (US);
Russell Dushin, Old Lyme, CT (US);
PFIZER INC., New York, NY (US);
RINAT NEUROSCIENCE CORP., South San Francisco, CA (US);
Abstract
The present invention provides engineered polypeptide conjugates (e.g., antibody-drug-conjugates, toxin-(biocompatible polymer) conjugates, antibody-(biocompatible polymer) conjugates, and bispecific antibodies) comprising acyl donor glutamine-containing tags and amine donor agents. In one aspect, the invention provides an engineered Fc-containing polypeptide conjugate comprising the formula (Fc-containing polypeptide)-T-A, wherein T is an acyl donor glutamine-containing tag engineered at a specific site or comprises an endogenous glutamine made reactive by the Fc-containing polypeptide engineering, wherein A is an amine donor agent, and wherein the amine donor agent is site-specifically conjugated to the acyl donor glutamine-containing tag or the endogenous glutamine. The invention also provides methods of making engineered polypeptide conjugates using transglutaminase.