The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 13, 2017
Filed:
Jan. 10, 2013
Applicant:
Biogen Idec MA Inc., Cambridge, MA (US);
Inventors:
Graham K. Farrington, Acton, MA (US);
William Sisk, Boxborough, MA (US);
Assignee:
Biogen MA Inc., Cambridge, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/00 (2006.01); C07K 16/28 (2006.01); C07K 16/46 (2006.01); C07K 14/415 (2006.01); C07K 14/47 (2006.01);
U.S. Cl.
CPC ...
C07K 16/28 (2013.01); C07K 14/415 (2013.01); C07K 14/4702 (2013.01); C07K 16/46 (2013.01); A61K 39/00 (2013.01); A61K 2039/505 (2013.01); C07K 2317/22 (2013.01); C07K 2317/569 (2013.01); C07K 2317/64 (2013.01); C07K 2317/70 (2013.01); C07K 2317/92 (2013.01); C07K 2317/94 (2013.01); C07K 2319/00 (2013.01); C07K 2319/30 (2013.01); C07K 2319/33 (2013.01);
Abstract
The invention is based, at least in part, on the finding that a dimeric version of a BBB-transmigrating antibody (e.g., the TMEM30A (CDC-50A) binding antibody, FC5) was found to greatly enhance transport across the BBB as compared to monovalent FC5 V. The invention provides, inter alia, molecules that increase transport of pharmacologically active agents across the blood brain barrier, methods for increasing transport across the blood brain barrier, and methods of treatment of disorders or diseases having a neurological component.