The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 13, 2017
Filed:
Sep. 30, 2016
Applicant:
Hoffmann-la Roche Inc., Little Falls, NJ (US);
Inventors:
Barbara Biemans, Basel, CH;
Wolfgang Guba, Muellheim, DE;
Georg Jaeschke, Basel, CH;
Antonio Ricci, Birsfelden, CH;
Daniel Rueher, Raedersdorf, FR;
Eric Vieira, Frenkendorf, CH;
Assignee:
HOFFMANN-LA ROCHE INC., Little Falls, NJ (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 239/96 (2006.01); C07D 487/06 (2006.01); C07D 475/04 (2006.01); C07D 473/04 (2006.01); C07D 401/04 (2006.01); C07D 513/04 (2006.01); C07D 495/04 (2006.01); C07D 239/91 (2006.01); C07D 471/04 (2006.01); C07D 487/04 (2006.01); C07D 405/04 (2006.01); C07D 401/10 (2006.01); C07D 405/14 (2006.01); C07D 475/02 (2006.01);
U.S. Cl.
CPC ...
C07D 239/96 (2013.01); C07D 401/04 (2013.01); C07D 401/10 (2013.01); C07D 405/04 (2013.01); C07D 405/14 (2013.01); C07D 473/04 (2013.01); C07D 475/02 (2013.01); C07D 487/04 (2013.01); C07D 487/06 (2013.01); C07D 495/04 (2013.01); C07D 513/04 (2013.01);
Abstract
It has been surprisingly been found that the compounds of general formula I are positive allosteric modulators (PAMs) of metabotropic glutamate receptor 4 (mGluR4), useful for the treatment of Parkinson's disease, anxiety, emesis, obsessive compulsive disorder, autism, neuroprotection, cancer, depression and diabetes type 2.