The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 30, 2017
Filed:
Jul. 08, 2014
Applicant:
Xencor, Inc., Monrovia, CA (US);
Inventors:
Gregory Lazar, Indianapolis, IN (US);
Wei Dang, Pasadena, CA (US);
John Desjarlais, Pasadena, CA (US);
Sher Karki, Santa Monica, CA (US);
Omid Vafa, Monrovia, CA (US);
Robert Hayes, Radnor, PA (US);
Jost Vielmetter, Altadena, CA (US);
Assignee:
Xencor, Inc., Monrovia, CA (US);
Primary Examiner:
Int. Cl.
CPC ...
C07H 21/04 (2006.01); C12P 21/06 (2006.01); C12N 1/20 (2006.01); C12N 5/02 (2006.01); C07K 16/28 (2006.01); C07K 16/00 (2006.01); C07K 16/32 (2006.01); C07K 16/30 (2006.01); C07K 16/18 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C07K 16/2893 (2013.01); C07K 16/00 (2013.01); C07K 16/18 (2013.01); C07K 16/2863 (2013.01); C07K 16/2887 (2013.01); C07K 16/2896 (2013.01); C07K 16/30 (2013.01); C07K 16/32 (2013.01); A61K 2039/505 (2013.01); C07K 2316/52 (2013.01); C07K 2317/24 (2013.01); C07K 2317/31 (2013.01); C07K 2317/34 (2013.01); C07K 2317/40 (2013.01); C07K 2317/41 (2013.01); C07K 2317/52 (2013.01); C07K 2317/56 (2013.01); C07K 2317/64 (2013.01); C07K 2317/71 (2013.01); C07K 2317/72 (2013.01); C07K 2317/732 (2013.01); C07K 2317/734 (2013.01); C07K 2317/77 (2013.01); C07K 2317/92 (2013.01); C07K 2317/94 (2013.01);
Abstract
The present invention relates to Fc variants having decreased affinity for FcγRIIb, methods for their generation, Fc polypeptides comprising optimized Fc variants, and methods for using optimized Fc variants.