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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9657013 B1

PDFFull Text
Date of Patent:
May. 23, 2017

Filed:

Feb. 28, 2013

Inhibitors of hepatitis b virus covalently closed circular dna formation and their method of use

Applicants:

Baruch S. Blumberg Institute, Doylestown, PA (US);

Drexel University, Philadelphia, PA (US);

Inventors:

Andrea Cuconati, Oreland, PA (US);

Haitao Guo, Lansdale, PA (US);

Timothy M. Block, Doylestown, PA (US);

Ju-Tao Guo, Lansdale, PA (US);

Xiaodong Xu, Doylestown, PA (US);

Huagang Lu, Plainsboro, NJ (US);

Dawei Cai, Doylestown, PA (US);

Assignees:

Baruch S. Blumberg Institute, Doylestown, PA (US);

Drexel University, Philadelphia, PA (US);

Attorneys:

Saul Ewing LLP

Kathryn Doyle

Domingos J. Silva

Primary Examiner:

Samantha Shterengarts

Int. Cl.
CPC ...
A61K 31/4409 (2006.01); A61K 31/505 (2006.01); A61K 31/4465 (2006.01); A61K 31/445 (2006.01); A61K 31/428 (2006.01); A61K 31/165 (2006.01); A61K 31/495 (2006.01); C07D 471/04 (2006.01); C07D 263/56 (2006.01); C07D 213/76 (2006.01); C07D 235/08 (2006.01); C07D 401/12 (2006.01); C07D 239/26 (2006.01); C07D 209/08 (2006.01); C07D 277/64 (2006.01); C07D 211/26 (2006.01); C07D 213/40 (2006.01); C07C 311/21 (2006.01); C07D 295/135 (2006.01); C07C 317/32 (2006.01); C07D 211/34 (2006.01); C07D 211/60 (2006.01); C07D 213/56 (2006.01); C07D 295/155 (2006.01);
U.S. Cl.
CPC ...
C07D 471/04 (2013.01); A61K 31/445 (2013.01); A61K 31/4409 (2013.01); A61K 31/4465 (2013.01); A61K 31/505 (2013.01); C07C 311/21 (2013.01); C07C 317/32 (2013.01); C07D 209/08 (2013.01); C07D 211/26 (2013.01); C07D 211/34 (2013.01); C07D 211/60 (2013.01); C07D 213/40 (2013.01); C07D 213/56 (2013.01); C07D 213/76 (2013.01); C07D 235/08 (2013.01); C07D 239/26 (2013.01); C07D 263/56 (2013.01); C07D 277/64 (2013.01); C07D 295/135 (2013.01); C07D 295/155 (2013.01); C07D 401/12 (2013.01);
Abstract

Pharmaceutical compositions of the invention comprise covalently closed circular DNA formation inhibitors having a disease-modifying action in the treatment of diseases associated with the formation of covalently closed circular DNA that include hepatitis B infection, and any disease involving formation of covalently closed circular DNA.

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