The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 09, 2017
Filed:
Jan. 30, 2014
Applicant:
The General Hospital Corporation, Boston, MA (US);
Inventors:
Gary J. Brenner, Winchester, MA (US);
Xandra O. Breakefield, Newton, MA (US);
Giulia Fulci, Cambridge, MA (US);
Assignee:
The General Hospital Corporation, Boston, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/00 (2006.01); A61K 48/00 (2006.01); C12N 15/86 (2006.01); C12N 9/16 (2006.01);
U.S. Cl.
CPC ...
C12N 15/86 (2013.01); A61K 48/005 (2013.01); C12N 9/16 (2013.01); C12N 2750/14143 (2013.01); C12N 2830/008 (2013.01); C12Y 304/22036 (2013.01);
Abstract
Described herein are compositions and methods for treating, inhibiting, preventing, reducing the severity of and/or reducing the progression of schwannoma, as well as any disease or physiological disease-state in which schwannoma plays a role. The compositions comprise an rAAV vector that includes a caspase-1 gene or a variant thereof and a Schwann cell specific promoter.