The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 09, 2017
Filed:
Nov. 20, 2012
The Trustees of the University of Pennsylvania, Philadelphia, PA (US);
The United States of America, As Represented BY the Secretary of the Department of Health and Human Services, Washington, DC (US);
James L. Riley, Downingtown, PA (US);
Daniel H. Fowler, Bethesda, MD (US);
Shoba Amarnath, Washington, DC (US);
The Trustees of the University of Pennsylvania, Philadelphia, PA (US);
The United States of America, as Represented By The Secretary, Department of Health And Human Services, Washington, DC (US);
Abstract
The present invention provides methods and compositions for converting a T cell into a cell that exhibits at least one regulatory T cell phenotype. The converted T cell is generated by contacting a T cell with a cell that is modified to comprise an agent capable of activating PD1 signaling in a T cell. The converted T cell is useful for preventing, suppressing, blocking or inhibiting an immune response. For example the converted T cell is useful for preventing rejection of a transplanted tissue in a human or other animal host, or protecting against graft versus host disease. The converted T cell can also be used to treat autoimmune diseases.