The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 09, 2017
Filed:
Jan. 20, 2015
Institute of Basic Medical Science, the Academy of Military Medical Science of the Chinese Pla, Beijing, CN;
Gencheng Han, Beijing, CN;
Guojiang Chen, Beijing, CN;
Xingwei Jiang, Beijing, CN;
Renxi Wang, Beijing, CN;
He Xiao, Beijing, CN;
Chunmei Hou, Beijing, CN;
Jiahui Yu, Beijing, CN;
Zhi Zhao, Beijing, CN;
Jiannan Feng, Beijing, CN;
Yan Li, Beijing, CN;
Beifen Shen, Beijing, CN;
Abstract
The present invention provides a human Tim-3-Ig fusion protein which can block Tim-3 signal pathway, and said Ig fusion protein comprises Tim-3 protein, human Ig fragment, and the linking sequence therebetween. In the present invention, a human Tim-3-Ig gene is obtained by an artificial synthesis process; an expression vector containing the Tim-3-Ig gene is constructed; and the prepared Ig fusion protein is tested in an expression verification experiment, a binding activity experiment, a blocking activity experiment in different cell lines, and in vivo experiments in mice. The human Tim-3-Ig fusion protein prepared in the present invention can be used to treat immunological diseases caused by high expression of Tim-3.