The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 02, 2017

Filed:

Nov. 04, 2011
Applicants:

Shinya Yamanaka, Kyoto, JP;

Kazutoshi Takahashi, Kyoto, JP;

Koji Tanabe, Kyoto, JP;

Hong Hyenjong, Kyoto, JP;

Inventors:

Shinya Yamanaka, Kyoto, JP;

Kazutoshi Takahashi, Kyoto, JP;

Koji Tanabe, Kyoto, JP;

Hong Hyenjong, Kyoto, JP;

Assignee:

Kyoto University, Kyoto, JP;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/00 (2006.01); C12N 15/01 (2006.01); C12N 5/074 (2010.01); C12N 15/86 (2006.01); C12N 9/18 (2006.01); C12N 9/12 (2006.01);
U.S. Cl.
CPC ...
C12N 15/01 (2013.01); C12N 5/0696 (2013.01); C12N 9/12 (2013.01); C12N 9/18 (2013.01); C12N 15/86 (2013.01); C12N 2501/405 (2013.01); C12N 2501/60 (2013.01); C12N 2501/602 (2013.01); C12N 2501/603 (2013.01); C12N 2501/604 (2013.01); C12N 2501/605 (2013.01); C12N 2501/606 (2013.01); C12N 2501/999 (2013.01);
Abstract

Provided is a method of improving the efficiency of iPS cell establishment, comprising bringing one or more factors selected from the group consisting of proteins belonging to cyclin D family and nucleic acids that encode the same into contact with a somatic cell, in the step of nuclear reprogramming of the somatic cell. Also provided are a method of producing an iPS cell comprising the step of bringing the factor(s) and nuclear reprogramming substance(s) into contact with a somatic cell, an iPS cell comprising a nucleic acid that encodes a protein belonging to cyclin D family that can be obtained by the method of producing an iPS cell, and a method of somatic cell production by forcing the iPS cell to differentiate.


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