The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 02, 2017
Filed:
Jul. 23, 2009
Dae Hae Song, Seoul, KR;
Jae Hee Shin, Suwon-si, KR;
MI Ji Lee, Incheon, KR;
Sung Hee Hong, Suwon-si, KR;
SE Chang Kwon, Seoul, KR;
Gwan Sun Lee, Seoul, KR;
Dae Hae Song, Seoul, KR;
Jae Hee Shin, Suwon-si, KR;
Mi Ji Lee, Incheon, KR;
Sung Hee Hong, Suwon-si, KR;
Se Chang Kwon, Seoul, KR;
Gwan Sun Lee, Seoul, KR;
HANMI SCIENCE CO., LTD., Hwaseong-si, KR;
Abstract
Disclosed is a protein complex, comprising a physiologically active polypeptide, a dimeric protein and a non-peptidyl polymer having three functional ends (3-arm), with the linkage of both the physiologically active polypeptide and the dimeric protein to the 3-arm non-peptidyl polymer via respective covalent bonds. The protein complex guarantees the long acting activity and biostability of a physiologically active polypeptide. Having the ability to maintain the bioactivity of physiologically active polypeptides or peptides highly and to significantly improve the serum half life of the polypeptides or peptides, the protein complex can be applied to the development of sustained release formulations of various physiologically active polypeptide drugs. Also, it utilizes raw materials including the physiologically active polypeptides without significant loss, thereby increasing the production yield. Further, it can be easily purified.