The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 02, 2017
Filed:
Sep. 27, 2013
Applicant:
The University of North Carolina AT Chapel Hill, Chapel Hill, NC (US);
Inventors:
Thomas McCown, Carrboro, NC (US);
Steven Gray, Mebane, NC (US);
Assignee:
The University of North Carolina at Chapel Hill, Chapel Hill, NC (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 48/00 (2006.01); A61K 39/12 (2006.01); A61K 39/23 (2006.01); C07K 14/00 (2006.01); C12N 7/00 (2006.01); C12N 15/00 (2006.01); A61K 35/76 (2015.01); C12N 15/86 (2006.01); C07K 14/005 (2006.01); A61K 9/00 (2006.01); C07K 14/015 (2006.01); C12N 15/864 (2006.01);
U.S. Cl.
CPC ...
A61K 35/76 (2013.01); A61K 9/0085 (2013.01); C07K 14/005 (2013.01); C12N 7/00 (2013.01); C12N 15/86 (2013.01); A61K 39/23 (2013.01); C07K 14/015 (2013.01); C12N 15/8645 (2013.01); C12N 2750/14122 (2013.01); C12N 2750/14142 (2013.01); C12N 2750/14143 (2013.01); C12N 2750/14145 (2013.01); C12N 2810/6027 (2013.01);
Abstract
The invention relates to chimeric AAV capsids targeted to oligodendrocytes, nucleic acids encoding the capsids, virus vectors and particles comprising the same, methods of producing the vectors, and methods of using the vectors to target oligodendrocytes. The invention further relates to methods of treating a disorder associated with oligodendrocyte dysfunction using the vectors.