The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 18, 2017
Filed:
Jul. 02, 2010
Michelle Bradbury, New York, NY (US);
Ulrich Wiesner, Ithaca, NY (US);
Oula Penate Medina, New York, NY (US);
Hoosweng Ow, Arlington, MA (US);
Andrew Burns, Niskayuna, NY (US);
Jason Lewis, New York, NY (US);
Steven Larson, New York, NY (US);
Michelle Bradbury, New York, NY (US);
Ulrich Wiesner, Ithaca, NY (US);
Oula Penate Medina, New York, NY (US);
Hoosweng Ow, Arlington, MA (US);
Andrew Burns, Niskayuna, NY (US);
Jason Lewis, New York, NY (US);
Steven Larson, New York, NY (US);
Sloan-Kettering Institute for Cancer Research, New York, NY (US);
Cornell University, Ithaca, NY (US);
Abstract
The present invention provides a fluorescent silica-based nanoparticle that allows for precise detection, characterization, monitoring and treatment of a disease such as cancer The nanoparticle has a fluorescent compound positioned within the nanoparticle, and has greater brightness and fluorescent quantum yield than the free fluorescent compound To facilitate efficient urinary excretion of the nanoparticle, it may be coated with an organic polymer, such as polyethylene glycol) (PEG) The small size of the nanoparticle, the silica base and the organic polymer coating minimizes the toxicity of the nanoparticle when administered in vivo The nanoparticle may further be conjugated to a ligand capable of binding to a cellular component associated with the specific cell type, such as a tumor marker A therapeutic agent may be attached to the nanoparticle Radionuclides/radiometals or paramagnetic ions may be conjugated to the nanoparticle to permit the nanoparticle to be detectable by various imaging techniques.