The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Feb. 28, 2017

Filed:

Mar. 14, 2013
Applicant:

Genentech, Inc., South San Francisco, CA (US);

Inventors:

Sunil Bhakta, South San Francisco, CA (US);

Meredith Hazen, South San Francisco, CA (US);

Jo-Anne S Hongo, South San Francisco, CA (US);

Jagath R Junutula, South San Francisco, CA (US);

Isidro Hotzel, South San Francisco, CA (US);

Yonglei Shang, South San Francisco, CA (US);

Shang-Fan Yu, South San Francisco, CA (US);

Assignee:

Genentech, Inc., South San Francisco, CA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/395 (2006.01); C07K 16/30 (2006.01); A61K 47/48 (2006.01); A61K 51/10 (2006.01); C12Q 1/68 (2006.01); G01N 33/574 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C07K 16/30 (2013.01); A61K 47/48384 (2013.01); A61K 47/48407 (2013.01); A61K 47/48438 (2013.01); A61K 47/48584 (2013.01); A61K 51/1051 (2013.01); C12Q 1/6886 (2013.01); G01N 33/57415 (2013.01); G01N 33/57423 (2013.01); A61K 2039/505 (2013.01); A61K 2039/6037 (2013.01); C07K 2317/24 (2013.01); C07K 2317/76 (2013.01); C07K 2317/77 (2013.01); C12Q 2600/158 (2013.01); C12Q 2600/16 (2013.01); G01N 2333/47 (2013.01); G01N 2500/02 (2013.01);
Abstract

The present invention is directed to compositions of matter useful for the diagnosis and treatment of tumor in mammals and to methods of using those compositions of matter for the same. In certain aspects, the isolated nucleic acid molecule comprises a nucleotide sequence having at least about 80% nucleic acid sequence identity, alternatively at least about 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or 100% nucleic acid sequence identity, to (a) a DNA molecule encoding a full-length TAT polypeptide having an amino acid sequence as disclosed herein, a TAT polypeptide amino acid sequence lacking the signal peptide as disclosed herein, an extracellular domain of a transmembrane TAT polypeptide, with or without the signal peptide, as disclosed herein.


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