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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9580411 B1

PDFFull Text
Date of Patent:
Feb. 28, 2017

Filed:

Mar. 27, 2015

Substituted sulfonamide compounds

Applicants:

Hoffmann-la Roche Inc., Little Falls, NJ (US);

Genentech, Inc., South San Francisco, CA (US);

Inventors:

Christine E. Brotherton-Pleiss, Sunnyvale, CA (US);

Huifen Chen, Burlingame, CA (US);

Shaoqing Chen, Bridgewater, NJ (US);

Zhi Chen, Livingston, NJ (US);

Shawn David Erickson, Leonia, NJ (US);

Anthony Estrada, San Carlos, CA (US);

Kyungjin Kim, Livingston, NJ (US);

Hongju Li, Edison, NJ (US);

Allen John Lovey, North Caldwell, NJ (US);

Joseph P. Lyssikatos, Piedmont, CA (US);

Yimin Qian, Wayne, NJ (US);

Sung-Sau So, Verona, NJ (US);

Peter Michael Wovkulich, New York, NY (US);

Lin Yi, Basking Ridge, NJ (US);

Assignee:

Hoffmann-La Roche Inc., Little Falls, NJ (US);

Attorney:

Robert C. Hall

Primary Examiner:

Alexander R Pagano

Int. Cl.
CPC ...
C07D 305/08 (2006.01); C07D 409/12 (2006.01); C07D 231/18 (2006.01); C07D 401/04 (2006.01); C07D 401/12 (2006.01); C07D 403/04 (2006.01); C07D 237/08 (2006.01); C07D 239/42 (2006.01); C07D 409/14 (2006.01); C07D 241/12 (2006.01); C07D 213/26 (2006.01); C07D 213/40 (2006.01); C07C 311/19 (2006.01); C07C 311/16 (2006.01); C07C 311/17 (2006.01); C07C 311/20 (2006.01); C07D 239/26 (2006.01); C07D 305/06 (2006.01); C07D 403/12 (2006.01);
U.S. Cl.
CPC ...
C07D 409/12 (2013.01); C07C 311/16 (2013.01); C07C 311/17 (2013.01); C07C 311/19 (2013.01); C07C 311/20 (2013.01); C07D 213/26 (2013.01); C07D 213/40 (2013.01); C07D 231/18 (2013.01); C07D 237/08 (2013.01); C07D 239/26 (2013.01); C07D 239/42 (2013.01); C07D 241/12 (2013.01); C07D 305/06 (2013.01); C07D 305/08 (2013.01); C07D 401/04 (2013.01); C07D 401/12 (2013.01); C07D 403/04 (2013.01); C07D 403/12 (2013.01); C07D 409/14 (2013.01); C07C 2101/02 (2013.01);
Abstract

The invention is concerned with the compounds of formula (I): and salts thereof, wherein X, Y, Z, R, R, R, R, R, Rand Rare defined in the detailed description and claims. In addition, the present invention relates to methods of manufacturing and using the compounds of Formula (I) as well as pharmaceutical compositions containing such compounds. The compounds may be useful in treating diseases and conditions mediated by TRPA1, such as pain.

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