The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 21, 2017
Filed:
May. 13, 2014
Applicant:
President and Fellows of Harvard College, Cambridge, MA (US);
Inventors:
Randall King, Newton, MA (US);
Xing Zeng, Brookline, MA (US);
Katharine L. Sackton, Somerville, MA (US);
Assignee:
President and Fellows of Harvard College, Cambridge, MA (US);
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 31/27 (2006.01); A61K 31/506 (2006.01); A61P 35/00 (2006.01); A61N 5/10 (2006.01); A61K 45/06 (2006.01); A61K 31/436 (2006.01); A61K 31/138 (2006.01); A61K 31/337 (2006.01); A61K 31/4196 (2006.01); A61K 31/496 (2006.01); A61K 31/555 (2006.01); A61K 47/48 (2006.01);
U.S. Cl.
CPC ...
A61K 31/27 (2013.01); A61K 31/138 (2013.01); A61K 31/337 (2013.01); A61K 31/4196 (2013.01); A61K 31/436 (2013.01); A61K 31/496 (2013.01); A61K 31/506 (2013.01); A61K 31/555 (2013.01); A61K 45/06 (2013.01); A61K 47/48038 (2013.01); A61N 5/1001 (2013.01); A61N 2005/109 (2013.01); A61N 2005/1021 (2013.01);
Abstract
The disclosure provides compositions and methods for treating cell cycle disorders. Compositions of the disclosure include proTAME, a prodrug analog of TAME and apcin, the combination of which inhibits an activity or function of the anaphase promoting complex (APC) by a synergistic mechanism.