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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9556178 B1

PDFFull Text
Date of Patent:
Jan. 31, 2017

Filed:

Nov. 04, 2014

Imidazotriazinecarbonitriles useful as kinase inhibitors

Applicant:

Bristol-myers Squibb Company, Princeton, NJ (US);

Inventors:

Ashok Vinayak Purandare, Pennington, NJ (US);

Brian E. Fink, Yardley, PA (US);

Ashvinikumar V. Gavai, Princeton Junction, NJ (US);

Walter Lewis Johnson, Waterbury, CT (US);

Amy C. Hart, Ewing, NJ (US);

Liqi He, Furlong, PA (US);

Tram N. Huynh, Pennington, NJ (US);

Jennifer Inghrim, Plainsboro, NJ (US);

Harold Mastalerz, Guilford, CT (US);

Xiaopeng Sang, Glastonbury, CT (US);

Christine M. Tarby, Lawrenceville, NJ (US);

Honghe Wan, Pennington, NJ (US);

Wayne Vaccaro, Yardley, PA (US);

Guifen Zhang, Wallingford, CT (US);

Yufen Zhao, Pennington, NJ (US);

Kurt Zimmermann, Durham, CT (US);

Assignee:

Bristol-Myers Squibb Company, Princeton, NJ (US);

Attorneys:

Elliott Korsen

Hong Liu

Primary Examiner:

Samira Jean-Louis

Int. Cl.
CPC ...
C07D 487/04 (2006.01); C07D 487/22 (2006.01); C07D 403/04 (2006.01); A61K 31/53 (2006.01); A61K 31/5377 (2006.01); A61K 31/5383 (2006.01); A61K 31/551 (2006.01); A61K 31/675 (2006.01); A61K 45/06 (2006.01); C07D 471/10 (2006.01); C07D 487/10 (2006.01); C07D 498/04 (2006.01); C07F 9/6521 (2006.01); A61K 31/541 (2006.01); A61K 31/55 (2006.01); C07D 487/08 (2006.01); C07D 519/00 (2006.01); C07F 9/6561 (2006.01); C07F 7/18 (2006.01);
U.S. Cl.
CPC ...
C07D 487/04 (2013.01); A61K 31/53 (2013.01); A61K 31/5377 (2013.01); A61K 31/5383 (2013.01); A61K 31/541 (2013.01); A61K 31/55 (2013.01); A61K 31/551 (2013.01); A61K 31/675 (2013.01); A61K 45/06 (2013.01); C07D 471/10 (2013.01); C07D 487/08 (2013.01); C07D 487/10 (2013.01); C07D 498/04 (2013.01); C07D 519/00 (2013.01); C07F 7/1804 (2013.01); C07F 9/6561 (2013.01); C07F 9/65213 (2013.01); C07F 9/65616 (2013.01); C07D 487/22 (2013.01);
Abstract

The invention provides compounds of Formula (I) and pharmaceutically acceptable salts thereof. The Formula (I) imidazotriazines inhibit protein kinase activity thereby making them useful as anticancer agents.

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