The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 27, 2016
Filed:
May. 31, 2013
Applicant:
The Uab Research Foundation, Birmingham, AL (US);
Inventors:
Tong Zhou, Birmingham, AL (US);
Robert P. Kimberly, Birmingham, AL (US);
Assignee:
The UAB Research Foundation, Birmingham, AL (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N 33/566 (2006.01); A61K 39/395 (2006.01); G01N 33/574 (2006.01); C07K 16/28 (2006.01); C07K 16/40 (2006.01); G01N 33/68 (2006.01); C12Q 1/68 (2006.01); C07K 14/715 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
G01N 33/57492 (2013.01); A61K 39/39558 (2013.01); C07K 16/2878 (2013.01); C07K 16/40 (2013.01); C12Q 1/6886 (2013.01); G01N 33/574 (2013.01); G01N 33/6863 (2013.01); A61K 2039/505 (2013.01); C07K 2317/34 (2013.01); G01N 2333/70578 (2013.01); G01N 2333/7151 (2013.01); G01N 2333/914 (2013.01); G01N 2500/02 (2013.01); G01N 2800/44 (2013.01);
Abstract
Provided herein is a method of reversing or preventing a target cell's resistance to a death receptor agonist. Also provided are methods of screening for biomarkers resistance of and monitoring resistance to death receptor agonists. Also provided are methods of selectively inducing apoptosis in a target cell, treating a subject with cancer, autoimmune or inflammatory diseases, comprising administering compositions provided herein. Further provided are compositions comprising agents that modulate CARD containing proteins.