The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 27, 2016
Filed:
Nov. 10, 2014
Research Triangle Institute, Research Triangle Park, NC (US);
Dignity Health, Phoenix, AZ (US);
Virginia Commonwealth University, Richmond, VA (US);
Frank Ivy Carroll, Durham, NC (US);
Bruce E. Blough, Raleigh, NC (US);
Hernan A. Navarro, Chapel Hill, NC (US);
S. Wayne Mascarella, Hillsborough, NC (US);
Ana Zamfira Muresan, Raleigh, NC (US);
M. Imad Damaj, Richmond, VA (US);
Ronald J. Lukas, Phoenix, AZ (US);
Research Triangle Institute, Research Triangle Park, NC (US);
Dignity Health, Phoenix, AZ (US);
Virginia Commonwealth University, Richmond, VA (US);
Abstract
The invention provides hydroxybupropion analogs capable of inhibiting the reuptake of one or more monoamines and/or acting as antagonists at nicotinic acetylcholine receptors. The compounds may selectively bind to one or more monoamine transporters, including those for dopamine, norepinephrine, and serotonin and/or may selectively bind to one or more nicotinic acetylcholine receptor subtypes. Such compounds may be used to treat conditions that are responsive to modification of monoamine levels and/or antagonism of nicotinic acetylcholine receptors, including drug dependency, depression, and obesity.