The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 22, 2016
Filed:
Jul. 25, 2012
Claire Ashman, Stevenage, GB;
Ian Richard Catchpole, Stevenage, GB;
Zoe Hughes-thomas, Stevenage, GB;
Alan Peter Lewis, Stevenage, GB;
Michael Steward, Stevenage, GB;
Claire Ashman, Stevenage, GB;
Ian Richard Catchpole, Stevenage, GB;
Zoe Hughes-Thomas, Stevenage, GB;
Alan Peter Lewis, Stevenage, GB;
Michael Steward, Stevenage, GB;
Glaxo Group Limited, Brentford, Middlesex, GB;
Abstract
The present invention is directed to antigen binding constructs comprising one or two epitope binding domains separated by a single chain Fc region of an antibody, wherein each epitope binding domain in capable of binding to VEGF, to dimers comprising two antigen binding constructs of the invention, pharmaceutical compositions comprising said dimers and their use in the treatment of diseases associated with VEGF signalling, such as diabetic macular edema (DME), wet age-related macular degeneration (Wet AMD), diabetic retinopathy, retinal vein occlusion (RVO), and corneal neovascularization, and polynucleotide sequences encoding said antigen binding constructs.