The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 15, 2016
Filed:
Feb. 04, 2015
Applicant:
Lipoxen Technologies Limited, London, GB;
Inventors:
Assignee:
Lipoxen Technologies Limited, London, GB;
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/00 (2006.01); A61K 47/48 (2006.01); A61K 38/18 (2006.01); C07K 14/535 (2006.01); C07K 14/52 (2006.01); C07K 14/505 (2006.01); C07K 14/575 (2006.01); A61K 38/46 (2006.01); A61K 38/19 (2006.01);
U.S. Cl.
CPC ...
A61K 47/4823 (2013.01); A61K 38/1816 (2013.01); A61K 38/193 (2013.01); A61K 38/465 (2013.01); C07K 14/505 (2013.01); C07K 14/52 (2013.01); C07K 14/535 (2013.01); C07K 14/575 (2013.01); A61K 38/00 (2013.01); C12Y 301/21001 (2013.01);
Abstract
The present invention relates to methods for producing N-terminal derivatives of proteins in which a polysaccharide, preferably having at least terminal sialic units, and preferably consisting essentially only of sialic acid units, is reacted at the N-terminus of a protein or peptide under controlled conditions to produce an N-terminal derivative. The controlled conditions include use of acidic pH for the derivatization step and a higher pH for purification. The derivatives are useful for improving pharmacokinetics and pharmacodynamics of proteins and peptides.