The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 15, 2016
Filed:
Apr. 04, 2011
Dae Hae Song, Hwaseong-si, KR;
Jae Hee Shin, Suwon-si, KR;
Young Jin Park, Suwon-si, KR;
Dae Seong Im, Yongin-si, KR;
Sung Min Bae, Seongnam-si, KR;
SE Chang Kwon, Seoul, KR;
Dae Hae Song, Hwaseong-si, KR;
Jae Hee Shin, Suwon-si, KR;
Young Jin Park, Suwon-si, KR;
Dae Seong Im, Yongin-si, KR;
Sung Min Bae, Seongnam-si, KR;
Se Chang Kwon, Seoul, KR;
HANMI SCIENCE CO., LTD., Hwaseong-si, KR;
Abstract
The present invention relates to an insulin conjugate having improved in vivo duration and stability, which is prepared by covalently linking insulin with an immunoglobulin Fc region via a non-peptidyl polymer, a long-acting formulation comprising the same, and a preparation method thereof. The insulin conjugate of the present invention maintains in vivo activity of the peptide at a relatively high level and remarkably increases the serum half-life thereof, thereby greatly improving drug compliance upon insulin treatment.