The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 25, 2016
Filed:
Jun. 19, 2014
The United States of America, As Represented BY the Secretary of Agriculture, Washington, DC (US);
The University of Connecticut, Storrs, CT (US);
Manuel V. Borca, Westbrook, CT (US);
Luis L. Rodriguez, Clinton, CT (US);
Peter W. Krug, Stony Brook, NY (US);
Vivian K. O'Donnell, Old Saybrook, CT (US);
The United States of America, as Represented by the Secretary of Agriculture, Washington, DC (US);
The University of Connecticut, Farmington, CT (US);
Abstract
We have developed an ASFV Georgia strain adapted to grow in Vero cell line. The resulting virus, ASF-GVAV, efficiently grows in Vero cells although it still is able to significantly replicate in primary cell cultures of swine macrophages. ASF-GVAV virus was successfully used as parental virus to develop several recombinant ASF viruses. The development of an ASFV adapted to grow in an established cell line is a significant advance for research and development of vaccine candidate strains using genetic manipulation based in the process of homologous recombination. The GVAVS can be utilized as a basis for large scale production of ASF vaccines.