The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 18, 2016

Filed:

May. 20, 2015
Applicant:

Tosk, Inc., Mountain View, CA (US);

Inventors:

William A. Garland, San Clemente, CA (US);

Brian D. Frenzel, Los Altos, CA (US);

Assignee:

Tosk, Inc., Mountain View, CA (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A01N 43/04 (2006.01); A61K 31/70 (2006.01); A61K 31/15 (2006.01); C07C 321/26 (2006.01); C07C 321/24 (2006.01); C07C 321/22 (2006.01); A61K 31/704 (2006.01); C07C 323/47 (2006.01); C07C 251/30 (2006.01); A61K 31/7028 (2006.01); A61K 31/7034 (2006.01);
U.S. Cl.
CPC ...
A61K 31/15 (2013.01); A61K 31/704 (2013.01); C07C 251/30 (2013.01); C07C 321/22 (2013.01); C07C 321/24 (2013.01); C07C 321/26 (2013.01); C07C 323/47 (2013.01); A61K 31/7028 (2013.01); A61K 31/7034 (2013.01);
Abstract

Methods are provided for using doxorubicin active agents in which reduced host toxicity is observed. Aspects of the methods including administering to a subject an effective amount of a doxorubicin active agent in conjunction with a doxorubicin toxicity-reducing adjuvant, e.g., a nitrone compound, or a nitrone compound in combination with a bisdioxopiperazine compound. Also provided are compositions for use in practicing the subject methods. The methods and compositions find use in a variety of different applications, including in the treatment of a variety of different disease conditions.


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