The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 04, 2016
Filed:
Aug. 15, 2014
Applicant:
Eleven Biotherapeutics, Inc., Cambridge, MA (US);
Inventors:
Thomas M. Barnes, Brookline, MA (US);
Jinzhao Hou, Belmont, MA (US);
Bracken M. King, Boston, MA (US);
Assignee:
ELEVEN BIOTHERAPEUTICS, INC., Cambridge, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/12 (2006.01); C07K 14/545 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C07K 14/545 (2013.01); A61K 38/00 (2013.01); C07K 2319/00 (2013.01);
Abstract
Featured herein are non-naturally occurring cytokine domains that can be used, inter alia, to modulate cellular signalling responsive to interleukin-1 receptor I (IL-1RI), to treat disorders, and to detect and/or bind to cellular receptors, as well as other agents. Exemplary cytokine domains can contain amino acid residues from at least two parental cytokines domains, for example, receptor binding features, surface features, β strands, and loops from at least two parental cytokines domains.