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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9447062 B1

PDFFull Text
Expired
Date of Patent:
Sep. 20, 2016

Filed:

Dec. 15, 2014

Manumycin-type metabolite called colabomycin e which inhibits caspase 1 and creation of interleukins, strain produces the colabomycin e and a method of a production of the colabomycin e

Applicants:

Biology Centre As Cr, V. V. I., Ceske Budejovice, CZ;

Institute of Microbiology As Cr, V. V. I., Prague, CZ;

Institute for Clinical and Experimental Medicine, Prague, CZ;

Inventors:

Miroslav Petricek, Prague, CZ;

Katerina Petrickova, Prague, CZ;

Stanislav Pospisil, Prague, CZ;

Marek Kuzma, Plzen, CZ;

Alica Chronakova, Pisek, SK;

Vaclav Kristufek, Ceske Budejovice, CZ;

Ilja Striz, Prague, CZ;

Assignees:

BIOLOGY CENTRE AS CR, V.V.I., Ceske Budejovice, CZ;

INSTITUTE OF MICROBIOLOGYH AS CR, V.V.I., Prague, CZ;

INSTITUTE FOR CLINICAL AND EXPERIMENTAL MEDICINE, Prague, CZ;

Attorney:

Notaro, Michalos & Zaccaria P.C.

Primary Examiner:

T Victor Oh

Int. Cl.
CPC ...
C07D 303/00 (2006.01); C07D 303/46 (2006.01); C12P 13/02 (2006.01);
U.S. Cl.
CPC ...
C07D 303/46 (2013.01); C12P 13/02 (2013.01);
Abstract

A manumycin-type metabolite called Colabomycin E which inhibits caspase 1 and creation of interleukins, strain produces the Colabomycin E and a method of a production of the Colabomycin E. Colabomycin E is a new member of the manumycin-type metabolites produced by the strainSOK1/5-04 deposited in The Czech collection of microorganisms under number CCM8556. The structure of 5 is similar to that of the already known metabolite colabomycin A (3) isolated from. However, the upper polyene chain of 5 is two carbons longer. Therefore, it was named Colabomycin E. Biological activity assays indicated that colabomycin E significantly inhibited IL-1β release from THP-1 cells and might thus potentially act as an anti-inflammatory agent.

Find Patent Forward Citations

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Petricek, Miroslav. (2016). Manumycin-type metabolite called colabomycin e which inhibits caspase 1 and creation of interleukins, strain produces the colabomycin e and a method of a production of the colabomycin e (U.S. Patent No. 9447062). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/9447062

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