The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 30, 2016
Filed:
May. 23, 2013
The United States of America, As Represented BY the Secretary, Department of Health and Human Services, Washington, DC (US);
The United States of America, As Represented BY the Secretary of the Army, Washington, DC (US);
Che-Hung Robert Lee, Silver Spring, MD (US);
Valerian B. Pinto, Frederick, MD (US);
The United States of America, as represented by the Secretary, Department of Health and Human Services, Washington, DC (US);
The United States of America, as Represented by the Secretary of the Army, Washington, DC (US);
Abstract
Disclosed herein are meningococcal immunogenic conjugates which can elicit immune responses against meningococcal polysaccharides (PS) from groups A, C, W-135, and Y and group B factor H binding protein (fHbp). The disclosed conjugates also exhibit bactericidal activity against meningococcal A, C, W-135, Y, B, and X serogroups. Also disclosed are improved methods for preparing conjugates, such as immunogenic conjugates, including activation of a polysaccharide with a cyanylation agent at about 4° C.