The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 23, 2016
Filed:
Mar. 17, 2014
Applicant:
Cold Spring Harbor Laboratory, Cold Spring Harbor, NY (US);
Inventors:
Joshua Dubnau, Huntington, NY (US);
Wanhe Li, New York, NY (US);
Lisa Prazak, Massapequa Park, NY (US);
Assignee:
Cold Spring Harbor Laboratory, Cold Spring Harbor, NY (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07H 21/02 (2006.01); C07H 21/04 (2006.01); C12Q 1/68 (2006.01);
U.S. Cl.
CPC ...
C12Q 1/6881 (2013.01); C12Q 1/6883 (2013.01); C12Q 2600/118 (2013.01); C12Q 2600/158 (2013.01);
Abstract
The present invention relates to transposon activation and mobilization, particularly in the brain, during normal aging; reporter systems to detect such mobilization, along with cells and transgenic animals containing such systems; methods of monitoring neuronal function during normal aging; methods of determining the risk of age-related neuronal decline and age-related mortality; and the use of transposon inhibitors and apoptosis inhibitors to delay age-related neuronal decline and age-related mortality.