The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 16, 2016
Filed:
Oct. 18, 2010
Applicants:
Jonathan F. Smith, Cary, NC (US);
Bolyn Hubby, Cary, NC (US);
Laura Copp, Raleigh, NC (US);
Inventors:
Assignee:
AlphaVax, Inc., Research Triangle Park, NC (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/12 (2006.01); C12N 15/86 (2006.01); A61K 39/145 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C12N 15/86 (2013.01); A61K 39/12 (2013.01); A61K 39/145 (2013.01); A61K 2039/5256 (2013.01); A61K 2039/70 (2013.01); C12N 2760/16134 (2013.01); C12N 2770/36143 (2013.01);
Abstract
The immune response to an antigen of interest, especially one in purified form, can be significantly enhanced by the simultaneous administration of an alphavirus replicon particle which expresses the same antigen. This allows for the use of significantly smaller quantities of the protein antigen than in conventional immunization strategies, and this new immunization strategy can also eliminate the need for boosting administration of the antigen or it can reduce the number of boosts required for an effective immune response to the antigen.