The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 09, 2016
Filed:
Mar. 08, 2013
Applicant:
Fibrogen, Inc., San Francisco, CA (US);
Inventors:
Wen-Bin Ho, Los Altos, CA (US);
Hongda Zhao, Dublin, CA (US);
Shaojiang Deng, Foster City, CA (US);
Danny Ng, Daly City, CA (US);
Lee R. Wright, Redwood City, CA (US);
Min Wu, Sunnyvale, CA (US);
Xiaoti Zhou, Burlingame, CA (US);
Michael P. Arend, Foster City, CA (US);
Lee A. Flippin, Woodside, CA (US);
Assignee:
FibroGen, Inc., San Francisco, CA (US);
Primary Examiner:
Int. Cl.
CPC ...
C07D 217/26 (2006.01); C07D 401/12 (2006.01); A61K 31/44 (2006.01); A61K 31/47 (2006.01); C07D 409/12 (2006.01); C07D 401/04 (2006.01); C07D 405/12 (2006.01);
U.S. Cl.
CPC ...
C07D 409/12 (2013.01); C07D 217/26 (2013.01); C07D 401/04 (2013.01); C07D 401/12 (2013.01); C07D 405/12 (2013.01);
Abstract
The present invention relates to novel compounds of formula (I), and compositions capable of inhibiting PHD1 enzyme activity selectively over other isoforms, for example, PHD2 and/or PHD3 enzymes. The invention also relates to compounds of formula (I) for use in disorders such as muscle degeneration, colitis, IBD, and certain ischemias.