The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 02, 2016
Filed:
Jul. 20, 2011
Sanne S. Veidal, Ølstykke, DK;
Morten A. Karsdal, Copenhagen Ø, DK;
Diana J. Leeming, Copenhagen SV, DK;
Natasha Barascuk, Copenhagen S, DK;
Helene Skjøt-arkil, Copenhagen S, DK;
Efstathios Vassiliadis, Rødovre, DK;
Sanne S. Veidal, Ølstykke, DK;
Morten A. Karsdal, Copenhagen Ø, DK;
Diana J. Leeming, Copenhagen SV, DK;
Natasha Barascuk, Copenhagen S, DK;
Helene Skjøt-Arkil, Copenhagen S, DK;
Efstathios Vassiliadis, Rødovre, DK;
Nordic Bioscience A/S, Herlev, DK;
Abstract
Methods of diagnosis or of quantitation of pathological conditions comprise conducting an immunoassay to measure neo-epitope containing protein fragments naturally present in a biofluid sample, and associating an elevation of the measure in the patient above a normal level with the presence or extent of pathology. The immunoassay is conducted by a method comprising: contacting protein fragments naturally present in the sample with an immunological binding partner reactive with a neo-epitope formed by cleavage of a protein by a proteinase and measuring the extent of binding of peptide fragments to the immunological binding partner to measure therein protein fragments comprising the neo-epitope. Neo-epitopes from, collagen type I, collagen type III, collagen type IV, collagen type V, collagen type VI, elastin, biglycan, decorin, lumican, versican, C-reactive protein, ApoE and laminins are described.