The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 02, 2016
Filed:
Oct. 21, 2011
James Hicks, Locust Valley, NY (US);
Nicholas Navin, Houston, TX (US);
Jennifer Troge, Oyster Bay, NY (US);
Zihua Wang, Huntington, NY (US);
Michael Wigler, Cold Spring Harbor, NY (US);
James Hicks, Locust Valley, NY (US);
Nicholas Navin, Houston, TX (US);
Jennifer Troge, Oyster Bay, NY (US);
Zihua Wang, Huntington, NY (US);
Michael Wigler, Cold Spring Harbor, NY (US);
Cold Spring Harbor Laboratory, Cold Spring Harbor, NY (US);
Abstract
A method for obtaining from genomic material genomic copy number information unaffected by amplification distortion, comprising obtaining segments of the genomic material, tagging the segments with substantially unique tags to generate tagged nucleic acid molecules, such that each tagged nucleic acid molecule comprises one segment of the genomic material and a tag, subjecting the tagged nucleic acid molecules to polymerase chain reaction (PCR) amplification, generating tag associated sequence reads by sequencing the product of the PCR reaction, assigning each tagged nucleic acid molecule to a location on a genome associated with the genomic material by mapping the subsequence of each tag associated sequence read corresponding to a segment of the genomic material to a location on the genome, and counting the number of tagged nucleic acid molecules assigned to the same location on the genome having a different tag, thereby obtaining genomic copy number information unaffected by amplification distortion.