The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 02, 2016
Filed:
Nov. 04, 2011
Applicants:
Chi-huey Wong, La Jolla, CA (US);
Che MA, New Taipei, TW;
Yung-chieh Tseng, New Taipei, TW;
Inventors:
Assignee:
Academia Sinica, Taipei, TW;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/145 (2006.01); C12N 7/00 (2006.01); C07K 14/005 (2006.01); C12P 21/00 (2006.01); A61K 39/12 (2006.01);
U.S. Cl.
CPC ...
C07K 14/005 (2013.01); A61K 39/12 (2013.01); A61K 39/145 (2013.01); C12N 7/00 (2013.01); C12P 21/005 (2013.01); C12Y 302/01096 (2013.01); C12N 2760/16111 (2013.01); C12N 2760/16123 (2013.01); C12N 2760/16134 (2013.01); C12N 2760/16151 (2013.01); G01N 2333/00 (2013.01); G01N 2333/11 (2013.01); Y02P 20/52 (2015.11);
Abstract
Methods for producing virus particles with simplified glycosylation on structural or surface proteins, such as mono-glycosylated forms of influenza A virus, NIBRG-14 (H5N1). When used as targets for vaccine production, the conserved nature of such sites generates vaccines that are less sensitive to viral mutations. Such methods may include the use of glycosylation inhibitors for production of viruses with simplified glycosylation profiles.