The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 02, 2016
Filed:
Feb. 22, 2011
Pooran Chand, Birmingham, AL (US);
Jason A. Chesney, Louisville, KY (US);
Brian F. Clem, Louisville, KY (US);
Gilles H. Tapolsky, Louisville, KY (US);
Sucheta Telang, Louisville, KY (US);
John O. Trent, Louisville, KY (US);
Pooran Chand, Birmingham, AL (US);
Jason A. Chesney, Louisville, KY (US);
Brian F. Clem, Louisville, KY (US);
Gilles H. Tapolsky, Louisville, KY (US);
Sucheta Telang, Louisville, KY (US);
John O. Trent, Louisville, KY (US);
Advanced Cancer Therapeutics, LLC, Louisville, KY (US);
University of Louisville Research Foundation, Inc., Louisville, KY (US);
Abstract
Small molecule inhibitors of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3) having the following formula: Formula (1) are provided herein. Also provided herein are pharmaceutical compositions containing Formula I compounds, together with methods of treating cancer, methods of inhibiting PFK.FB3 enzymatic activity, methods of inhibiting glycolytic flux, and methods of treating tumors by administering an effective amount of a Formula I compound.