The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 26, 2016
Filed:
Sep. 18, 2009
Paramjit S. Arora, Huntington, NY (US);
Bogdan Olenyuk, Sierra Madre, CA (US);
Ross N. Chapman, Tuckahoe, NY (US);
Laura Henchey, New York, NY (US);
Katherine M. Block, Chesterfield, MO (US);
Paramjit S. Arora, Huntington, NY (US);
Bogdan Olenyuk, Sierra Madre, CA (US);
Ross N. Chapman, Tuckahoe, NY (US);
Laura Henchey, New York, NY (US);
Katherine M. Block, Chesterfield, MO (US);
New York University, New York, NY (US);
The Arizona Board of Regents on Behalf of the University of Arizona, Tuscon, AZ (US);
Abstract
The present invention relates to peptides having one or more stable, internally constrained α-helices, and that include a sequence that mimics at least a portion of the C-terminal transactivation domain of HIF-1α. Also disclosed are pharmaceutical compositions containing these peptides and methods of using these peptides, for example to reduce gene transcription, treat or prevent disorders mediated by interaction of HIF-1α with CREB-binding protein and/or p300, reduce or prevent angiogenesis in a tissue, induce apoptosis, decrease cell survival and/or proliferation, and identify potential ligands of CREB-binding protein and/or p300.