The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jul. 12, 2016

Filed:

Jun. 06, 2012
Applicants:

Nagaraj Govindappa, Bangalore, IN;

Suma Sreenivas, Bangalore, IN;

Komal N. Kanojia, Bangalore, IN;

Yogesh Basavaraju, Bangalore, IN;

Kedamath Nanjund Sastry, Bangalore, IN;

Inventors:

Nagaraj Govindappa, Bangalore, IN;

Suma Sreenivas, Bangalore, IN;

Komal N. Kanojia, Bangalore, IN;

Yogesh Basavaraju, Bangalore, IN;

Kedamath Nanjund Sastry, Bangalore, IN;

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 14/62 (2006.01); A61K 38/28 (2006.01); C12P 21/02 (2006.01); C12N 15/81 (2006.01); C12N 9/64 (2006.01);
U.S. Cl.
CPC ...
C07K 14/62 (2013.01); C12N 9/6454 (2013.01); C12N 15/81 (2013.01); C12P 21/02 (2013.01); C12Y 304/21061 (2013.01); Y02P 20/52 (2015.11);
Abstract

The disclosure relates to a process of obtaining a fully folded two chain insulin glargine that require no further processing to make it functionally active. The present disclosure discloses a surprising effect of over expression of Kex2p intracellularly under the control of inducible FLD1 promoter in the hostto produce two chain functional glargine secreted directly in the medium. The schematic diagram of how the two chains are made inside the hostand secretes into the medium.


Find Patent Forward Citations

Govindappa, Nagaraj. (2016). Process of expressing a fully folded functional two chain insulin glargine (U.S. Patent No. 9388227). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/9388227

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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