The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 12, 2016
Filed:
Jun. 06, 2012
Nagaraj Govindappa, Bangalore, IN;
Suma Sreenivas, Bangalore, IN;
Komal N. Kanojia, Bangalore, IN;
Yogesh Basavaraju, Bangalore, IN;
Kedamath Nanjund Sastry, Bangalore, IN;
Nagaraj Govindappa, Bangalore, IN;
Suma Sreenivas, Bangalore, IN;
Komal N. Kanojia, Bangalore, IN;
Yogesh Basavaraju, Bangalore, IN;
Kedamath Nanjund Sastry, Bangalore, IN;
Biocon Limited, , IN;
Abstract
The disclosure relates to a process of obtaining a fully folded two chain insulin glargine that require no further processing to make it functionally active. The present disclosure discloses a surprising effect of over expression of Kex2p intracellularly under the control of inducible FLD1 promoter in the hostto produce two chain functional glargine secreted directly in the medium. The schematic diagram of how the two chains are made inside the hostand secretes into the medium.