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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9381172 B1

PDFFull Text
Date of Patent:
Jul. 05, 2016

Filed:

May. 12, 2012

Small molecule choline kinase inhibitors, screening assays, and methods for treatment of neoplastic disorders

Applicants:

Brian Clem, Louisville, KY (US);

Sucheta Telang, Louisville, KY (US);

John Trent, Louisville, KY (US);

Jason Chesney, Louisville, KY (US);

Pooran Chand, Birmingham, AL (US);

Gilles Tapolsky, Louisville, KY (US);

Inventors:

Brian Clem, Louisville, KY (US);

Sucheta Telang, Louisville, KY (US);

John Trent, Louisville, KY (US);

Jason Chesney, Louisville, KY (US);

Pooran Chand, Birmingham, AL (US);

Gilles Tapolsky, Louisville, KY (US);

Assignee:

UNIVERSITY OF LOUISVILLE RESEARCH FOUNDATION, INC., Louisville, KY (US);

Attorneys:

Calfee, Halter & Griswold LLP

Harry J. Guttman

Primary Examiner:

Bong-Sook Baek

Int. Cl.
CPC ...
A61K 31/4196 (2006.01); A61K 31/165 (2006.01); A61K 31/216 (2006.01); A61K 31/24 (2006.01); A61K 31/4166 (2006.01); A61K 31/426 (2006.01); A61K 31/427 (2006.01); A61K 31/428 (2006.01); A61K 31/4709 (2006.01); C07D 233/74 (2006.01); C07D 249/12 (2006.01); C07D 277/24 (2006.01); C07D 401/12 (2006.01); C07D 403/12 (2006.01); C07D 413/12 (2006.01); C07D 417/12 (2006.01);
U.S. Cl.
CPC ...
A61K 31/165 (2013.01); A61K 31/216 (2013.01); A61K 31/24 (2013.01); A61K 31/4166 (2013.01); A61K 31/4196 (2013.01); A61K 31/426 (2013.01); A61K 31/427 (2013.01); A61K 31/428 (2013.01); A61K 31/4709 (2013.01); C07D 233/74 (2013.01); C07D 249/12 (2013.01); C07D 277/24 (2013.01); C07D 401/12 (2013.01); C07D 403/12 (2013.01); C07D 413/12 (2013.01); C07D 417/12 (2013.01);
Abstract

Small molecule choline kinase inhibitors, pharmaceutical compositions thereof, and screening methods for identifying and evaluating choline kinase inhibitors are provided. Safe and effective methods for treating subjects suffering from a disorder or disease characterized by neoplastic cell proliferation employing the choline kinase inhibitors are also provided.

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