The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 28, 2016
Filed:
Nov. 27, 2013
Biomarin Pharmaceutical Inc., Novato, CA (US);
Mika Aoyagi-Scharber, Mill Valley, CA (US);
Teresa Margaret Christianson, Rohnert Park, CA (US);
Melita Dvorak-Ewell, Berkeley, CA (US);
Daniel J. Wendt, Walnut Creek, CA (US);
Shinong Long, San Ramon, CA (US);
Jonathan LeBowitz, Novato, CA (US);
Daniel Solomon Gold, San Francisco, CA (US);
BIOMARIN PHARMACEUTICAL INC., Novato, CA (US);
Abstract
The present invention relates in general to therapeutic fusion proteins useful to treat lysosomal storage diseases and methods for treating such diseases. Exemplary therapeutic fusion proteins comprise a lysosomal enzyme, a lysosomal targeting moiety, e.g., an IGF-II peptide, and a spacer peptide. Also provided are compositions and methods for treating Mucopolysaccharidosis Type IIIB (Sanfilippo B Syndrome), comprising a targeted therapeutic fusion protein comprising alpha-N-acetylglucosaminidase (Naglu), a lysosomal targeting moiety, e.g., an IGF-II peptide, and a spacer peptide.