The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 07, 2016
Filed:
Nov. 04, 2008
Applicants:
Morten Karsdal, Copenhagen, DK;
Per Qvist, Klampenborg, DK;
Natasha Barascuk, Copenhagen, DK;
Inventors:
Assignee:
NORDIC BIOSCIENCE A/S, Herlev, DK;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N 31/00 (2006.01); G01N 33/53 (2006.01); C12Q 1/37 (2006.01); C07K 14/775 (2006.01); G01N 33/542 (2006.01);
U.S. Cl.
CPC ...
C12Q 1/37 (2013.01); C07K 14/775 (2013.01); G01N 33/542 (2013.01); G01N 2800/32 (2013.01);
Abstract
A method of bioassay for the quantification of peptide fragments comprising a neo-epitope formed by cleavage of a protein of an atherosclerotic plaque such as lumican, versican, perlecan, decorin, biglycan, collagen type III, CRP, ApoE, or elastin, by a proteinase, said comprises contacting a sample such as urine or serum with an antibody reactive with the neo-epitope and determining the level of binding of said immunological binding partner to peptide fragments in said sample. The assay is predictive of risk of cardiovascular disease events.