The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 07, 2016
Filed:
Apr. 04, 2012
Applicants:
Sivanesan Dakshanamurthy, Hernon, VA (US);
Milton L. Brown, Brookeville, MD (US);
Robert Clarke, Rockville, MD (US);
Ayesha N. Shajahan-haq, Haymarket, VA (US);
Jacqueline Smith, Bowie, MD (US);
Inventors:
Sivanesan Dakshanamurthy, Hernon, VA (US);
Milton L. Brown, Brookeville, MD (US);
Robert Clarke, Rockville, MD (US);
Ayesha N. Shajahan-Haq, Haymarket, VA (US);
Jacqueline Smith, Bowie, MD (US);
Assignee:
Georgetown University, Washington, DC (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07D 213/32 (2006.01); A61K 31/4439 (2006.01); A61K 45/06 (2006.01); C07D 401/04 (2006.01); C07D 401/14 (2006.01); C07D 405/14 (2006.01); C07D 417/04 (2006.01); C07D 417/14 (2006.01); A61K 31/41 (2006.01); A61K 31/426 (2006.01); A61K 31/427 (2006.01); A61K 31/444 (2006.01);
U.S. Cl.
CPC ...
C07D 213/32 (2013.01); A61K 31/41 (2013.01); A61K 31/426 (2013.01); A61K 31/427 (2013.01); A61K 31/444 (2013.01); A61K 31/4439 (2013.01); A61K 45/06 (2013.01); C07D 401/04 (2013.01); C07D 401/14 (2013.01); C07D 405/14 (2013.01); C07D 417/04 (2013.01); C07D 417/14 (2013.01);
Abstract
Small molecule inhibitors of XBP1 splicing by IRE1 are provided, as well as methods for their use in treating or preventing cancer (e.g., endocrine resistant breast cancer), diabetes, and obesity.