IDiyas

For the Inventor, By the Inventor

The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9359289 B1

PDFFull Text
Date of Patent:
Jun. 07, 2016

Filed:

Jul. 30, 2013

Bioavailable diacylhydrazine ligands for modulating the expression of exogenous genes via an ecdysone receptor complex

Applicant:

Intrexon Corporation, Blacksburg, VA (US);

Inventors:

Robert Eugene Hormann, Melrose Park, PA (US);

David W. Potter, North Wales, PA (US);

Orestes Chortyk, Thompson Station, TN (US);

Colin M. Tice, Elkins Park, PA (US);

Glenn Richard Carlson, North Wales, PA (US);

Andrew Meyer, Maple Glen, PA (US);

Thomas R. Opie, North Wales, PA (US);

Assignee:

Intrexon Corporation, Blacksburg, VA (US);

Attorney:

Sterne, Kessler, Goldstein & Fox P.L.L.C.

Primary Examiner:

Savitha Rao

Assistant Examiner:

Gregg Polansky

Int. Cl.
CPC ...
C07C 243/24 (2006.01); C07D 319/18 (2006.01); C07C 241/04 (2006.01); C07C 243/38 (2006.01); C07C 251/08 (2006.01); C07C 251/38 (2006.01); C07C 255/66 (2006.01); C07C 281/10 (2006.01); C07C 309/59 (2006.01); C07C 317/44 (2006.01); C07C 317/46 (2006.01); C07D 209/42 (2006.01); C07D 213/81 (2006.01); C07D 213/82 (2006.01); C07D 231/14 (2006.01); C07D 231/56 (2006.01); C07D 235/06 (2006.01); C07D 237/24 (2006.01); C07D 239/52 (2006.01); C07D 241/24 (2006.01); C07D 271/12 (2006.01); C07D 317/68 (2006.01); C07D 405/12 (2006.01); C07C 243/18 (2006.01); C07D 213/87 (2006.01); C07D 319/20 (2006.01); C12N 9/02 (2006.01); C12N 15/63 (2006.01); C12P 21/00 (2006.01); A61K 31/166 (2006.01); A61K 31/222 (2006.01); A61K 31/357 (2006.01); A61K 31/404 (2006.01); A61K 31/415 (2006.01); A61K 31/4184 (2006.01); A61K 31/455 (2006.01); A61K 31/4965 (2006.01); C07C 315/02 (2006.01); C07D 213/86 (2006.01); C07D 235/24 (2006.01); C07D 319/08 (2006.01);
U.S. Cl.
CPC ...
C07C 241/04 (2013.01); A61K 31/166 (2013.01); A61K 31/222 (2013.01); A61K 31/357 (2013.01); A61K 31/404 (2013.01); A61K 31/415 (2013.01); A61K 31/4184 (2013.01); A61K 31/455 (2013.01); A61K 31/4965 (2013.01); C07C 243/18 (2013.01); C07C 243/24 (2013.01); C07C 243/38 (2013.01); C07C 251/08 (2013.01); C07C 251/38 (2013.01); C07C 255/66 (2013.01); C07C 281/10 (2013.01); C07C 309/59 (2013.01); C07C 315/02 (2013.01); C07C 317/44 (2013.01); C07C 317/46 (2013.01); C07D 209/42 (2013.01); C07D 213/81 (2013.01); C07D 213/82 (2013.01); C07D 213/86 (2013.01); C07D 213/87 (2013.01); C07D 231/14 (2013.01); C07D 231/56 (2013.01); C07D 235/06 (2013.01); C07D 235/24 (2013.01); C07D 237/24 (2013.01); C07D 239/52 (2013.01); C07D 241/24 (2013.01); C07D 271/12 (2013.01); C07D 317/68 (2013.01); C07D 319/08 (2013.01); C07D 319/18 (2013.01); C07D 319/20 (2013.01); C07D 405/12 (2013.01); C12N 9/0069 (2013.01); C12N 15/635 (2013.01); C12P 21/00 (2013.01);
Abstract

The present invention relates to non-steroidal ligands for use in nuclear receptor-based inducible gene expression system, and a method to modulate exogenous gene expression in which an ecdysone receptor complex comprising: a DNA binding domain; a ligand binding domain; a transactivation domain; and a ligand is contacted with a DNA construct comprising; the exogenous gene and a response element; wherein the exogenous gene is under the control of the response element and binding of the DNA binding domain to the response element in the presence of the ligand results in activation or suppression of the gene.

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