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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9357754 B1

PDFFull Text
Date of Patent:
Jun. 07, 2016

Filed:

Jan. 20, 2012

Transgenic pig expressing stnfr1-fc genes and the uses thereof

Applicants:

Curie Ahn, Gyeonggi-do, KR;

Byeong Chun Lee, Seoul, KR;

Jong Ik Hwang, Seoul, KR;

Jae Seok Yang, Seoul, KR;

Byoung Gon Moon, Daejeon, KR;

Goo Jang, Seoul, KR;

Bum Rae Cho, Seoul, KR;

OK Jae Koo, Seoul, KR;

Sol Ji Park, Seoul, KR;

Jung Taek Kang, Seoul, KR;

Dae Kee Kwon, Seoul, KR;

Inventors:

Curie Ahn, Gyeonggi-do, KR;

Byeong Chun Lee, Seoul, KR;

Jong Ik Hwang, Seoul, KR;

Jae Seok Yang, Seoul, KR;

Byoung Gon Moon, Daejeon, KR;

Goo Jang, Seoul, KR;

Bum Rae Cho, Seoul, KR;

Ok Jae Koo, Seoul, KR;

Sol Ji Park, Seoul, KR;

Jung Taek Kang, Seoul, KR;

Dae Kee Kwon, Seoul, KR;

Assignee:

SNU R&DB FOUNDATION, Seoul, KR;

Attorneys:

Joseph R. Baker, Jr.

Gavrilovich, Dodd & Lindsey LLP

Primary Examiner:

Deborah Crouch

Int. Cl.
CPC ...
A01K 67/027 (2006.01); C12N 15/00 (2006.01); C12P 21/00 (2006.01); C07K 14/705 (2006.01); C12N 15/85 (2006.01); A61D 19/04 (2006.01); C07K 16/18 (2006.01); C07K 14/715 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
A01K 67/0275 (2013.01); A61D 19/04 (2013.01); C07K 14/70578 (2013.01); C07K 16/18 (2013.01); C12N 15/8509 (2013.01); A01K 2207/15 (2013.01); A01K 2217/052 (2013.01); A01K 2227/108 (2013.01); A01K 2267/025 (2013.01); A61K 38/00 (2013.01); C07K 14/7151 (2013.01); C07K 2319/30 (2013.01);
Abstract

The present invention relates to a transgenic pig that expresses sTNFR1-Fc, wherein a gene encoding sTNFR1-Fc, which is a fusion protein of the extracellular domain of human soluble tumor necrosis factor receptor (sTNFR1) and an immunoglobulin Fc region, is introduced; a method for preparing the same; an organ isolated from the transgenic pig; a somatic donor cell line inserted with sTNFR1-Fc gene; a method for preparing a blood sample comprising sTNFR1-Fc; and a method for preparing human sTNFR1-Fc from the blood sample of the transgenic pig. As the transgenic pig can suppress immune response and inflammatory response by secreting an inhibitory substance that suppresses the activity of TNF-α in blood, it can be effectively used for xenograft. Furthermore, since the transgenic pig has a blood type O, it can be transplanted for suppressing inflammatory response, regardless of a blood type of recipient.

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