The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 17, 2016

Filed:

Nov. 19, 2012
Applicant:

Kao Corporation, Chuo-ku, Tokyo, JP;

Inventors:

Tomohiro Shirai, Utsunomiya, JP;

Hiroshi Kusuoku, Shimotsuke, JP;

Mitsuyoshi Sakasai, Kawasaki, JP;

Kentaro Kumihashi, Utsunomiya, JP;

Assignee:

Kao Corporation, Tokyo, JP;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07C 43/23 (2006.01); A61Q 11/00 (2006.01); A61K 8/34 (2006.01); A61Q 19/00 (2006.01); A61K 8/33 (2006.01); A61Q 1/00 (2006.01); A61Q 5/02 (2006.01);
U.S. Cl.
CPC ...
C07C 43/23 (2013.01); A61K 8/33 (2013.01); A61K 8/347 (2013.01); A61Q 1/00 (2013.01); A61Q 11/00 (2013.01); A61Q 19/00 (2013.01); A61K 2201/054 (2013.01); A61K 2800/10 (2013.01); A61K 2800/244 (2013.01); A61Q 5/02 (2013.01);
Abstract

Provided are a cooling agent having an excellent TRPM8 activating action, a TRPM8 activator, a method for imparting cooling sensation, and a novel compound useful for imparting cooling sensation. Disclosed is a cooling agent comprising, as an active ingredient, a compound represented by the following formula (1): wherein Rrepresents a hydrogen atom; Rrepresents a hydrogen atom, a hydroxyl group, or an alkoxy group having from 1 to 3 carbon atoms; Rrepresents a hydrogen atom or a hydroxyl group; Rrepresents a hydrogen atom, an alkyl group having from 1 to 6 carbon atoms, an alkenyl group having from 2 to 6 carbon atoms, or an alkoxy group having from 1 to 3 carbon atoms; Rrepresents a hydrogen atom or an alkoxy group having from 1 to 3 carbon atoms; and Rrepresents a hydrogen atom, a hydroxyl group, an alkoxy group having from 1 to 14 carbon atoms, an alkoxyalkoxy group having from 2 to 12 carbon atoms in total, a cycloalkoxy group having from 3 to 12 carbon atoms, an aryloxy group having from 6 to 12 carbon atoms, an aralkyloxy group having from 7 to 14 carbon atoms in total, or an alkanoyloxy group having from 2 to 12 carbon atoms in total.


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