The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 10, 2016
Filed:
Dec. 17, 2014
Applicant:
Taro Pharmaceutical Industries Limited, Haifa Bay, Haifa, IL;
Inventors:
Assignee:
TARO PHARMACEUTICAL INDUSTRIES LTD., Haifa Bay, IL;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07C 45/81 (2006.01); C07C 46/00 (2006.01);
U.S. Cl.
CPC ...
C07C 46/00 (2013.01); C07C 45/81 (2013.01); C07B 2200/13 (2013.01);
Abstract
The present invention provides a process for the preparation of a stable polymorph III of Atovaquone exhibiting characteristic peaks (expressed in degrees 20±0.2°θ) at about 6.9, 9.6, 14.1, 14.7, 17.0, 18.5, 19.1, 19.9, 20.3, 22.0, 22.6, 23.2, 24.2, 26.8, and 28.5, which comprises: (a) providing a sample of Atovaquone particles; (b) heating the sample of Atovaquone particles at a minimal temperature of between 140° C. to 160° C. depending on the particle size of the sample; and (c) cooling the sample to obtain the stable polymorphic form of Atovaquone.